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Tadalafil should only be used by men over the age of 18 who have erectile dysfunction. It should not be used with other treatments for erectile dysfunction. If you aren’t sure whether you have any of the conditions listed above, please consult your doctor. Yes, it's perfectly safe to buy ED medicine online as long as the provider you’re getting them from is reliable, reputable, and takes the appropriate steps to ensure your safety. We’re regulated by the Care Quality Commission (England’s independent regulator of health and social care) and follow strict safeguarding guidelines by the General Pharmaceutical Council (GPhC). Sildenafil typically lasts between 2 and 5 hours, while tadalafil can last up to 36 hours.
Sudden loss or decrease in hearing, sometimes with ringing in the ears and dizziness, has been rarely reported in people taking PDE5 inhibitors, including CIALIS. It is not possible to determine whether these events are related directly to the PDE5 inhibitors, to other diseases or medications, to other factors, or to a combination of factors. If you experience these symptoms, stop taking CIALIS and contact a healthcare provider right away. A study was conducted to assess the degree of interaction between nitroglycerin and tadalafil, should nitroglycerin be required in an emergency situation after tadalafil was taken. Subjects were administered a single dose of 0.4 mg sublingual nitroglycerin (NTG) at pre-specified timepoints, following their last dose of tadalafil (2, 4, 8, 24, 48, 72, and 96 hours after tadalafil). After 48 hours, the interaction was not detectable ( see Figure 1).
The placebo-subtracted mean maximal decreases in systolic blood pressure over a 12-hour period after dosing in the placebo-controlled portion of the study (part Cmax) are shown in Table 6 and Figure 3 . Therefore, CIALIS administration with nitrates is contraindicated. In such circumstances, nitrates should still only be administered under close medical supervision with appropriate hemodynamic monitoring [see CONTRAINDICATIONS] . In clinical pharmacology studies, tadalafil (5 to 20 mg) was shown to potentiate the hypotensive effect of nitrates. Therefore, the use of CIALIS in patients taking any form of nitrates is contraindicated [see CONTRAINDICATIONS] .
Cialis tablets should be stored in a dry place at room temperature (68-77 F). Cialis was also investigated in combination with finasteride, another BPH medication, in another trial. The results showed the combination to be even more effective than either medication alone. Interestingly, Cialis has been more linked to improved self-esteem and other psychological factors than the other PDE5 medications. Compared with other PDE5 inhibitors for ED, Cialis is similar in effectiveness to Viagra (sildenafil) and Levitra (vardenafil). In BPH, the medication relaxes the urinary tract and bladder muscles, allowing for more effortless urine flow.
Cialis also exaggerates the blood pressure lowering effects of some alpha-blocking drugs that primarily are used for treating high blood pressure or enlargement of the prostate (BPH). Although Viagra 
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