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The interaction of tadalafil with alcohol was evaluated in 3 clinical pharmacology studies. In both these studies, all patients imbibed the entire alcohol dose within 10 minutes of starting. In one of these two studies, blood alcohol levels of 0.08% were confirmed.

Therefore, the clinical experience with tadalafil is lacking compared to nifedipine, and it cannot be recommended to prevent HAPE in the absence of further study (Luks et al., 2014