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(An active ingredient is what makes a drug work.) Viagra belongs to a group of drugs called phosphodiesterase 5 (PDE5) inhibitors. The use of VIAGRA offers no protection against sexually transmitted diseases. VIAGRA is rapidly absorbed after oral administration, with a mean absolute bioavailability of 41% (range 25–63%). The pharmacokinetics of sildenafil are dose-proportional over the recommended dose range. It is eliminated predominantly by hepatic metabolism (mainly CYP3A4) and is converted to an active metabolite with properties similar to the parent, sildenafil.

Sildenafil inhibits (blocks) the enzyme PDE5 which regulates blood flow in the penis. PDE5 inhibitors multiply the natural process of arousal and increase blood flow to the penis in situations of sexual stimulation. Sildenafil helps to achieve an erection but relies on natural arousal as a trigger.

The Patient Information Leaflet enclosed with your medicine will detail a full list of side effects. Below, we’ll cover everything you need to know about Spedra, answering any questions you may have about the ED treatment to help determine if it’s right for you. A Felix online visit is considered asynchronous since it is conveniently completed through a secure chat bases system.

One of these chemicals, called cyclic GMP, relaxes and widens certain blood vessels in your penis. Cyclic GMP also relaxes the muscles around the erectile tissue in your penis that’s called the corpus cavernosum. These actions allow blood to flow into the corpus cavernosum, which causes your penis to get hard and become erect. This means that if you’re aroused, you should still be able to get an erection up to 4 hours after taking a dose of Viagra. Regardless of your age, you’ll take your prescribed dose about an hour before sex.

PDE5 inhibitors act to relax penile erectile tissues with sexual stimulation thus enhancing your ability to get an erection. Sildenafil (Viagra) is effective for all sorts of erectile dysfunction in 69% of people. In some cases the erection is not hard enough, sometimes sildenafil (Viagra) just doesn’t work. Sildenafil100 mg belongs to a group of medicines called phosphodiesterase type 5 (PDE 5) inhibitors. Sildenafilwill only help you to get an erection if you are sexually stimulated. All of these are mild side effects, and symptoms shouldn’t last more than a few hours.

Below are lists of medications that can interact with Viagra. These lists don’t contain all the drugs that may interact with Viagra. If you drink alcohol, talk with your doctor about how much is safe for you to drink while you’re taking Viagra. The manufacturer of Viagra doesn’t give any specific warnings about drinking alcohol while using this drug. But in general, it’s best to avoid drinking lots of alcohol with the medication. Keep in mind that Viagra isn’t approved in the United States to treat PE.

Start your online consultation today and our clinicians will make sure it’s safe for you to take. Patients taking sildenafil may experience headaches, nausea, flushing, stuffy nose, and on occasion, indigestion, or dizziness. Most of these side effects are transient and will disappear after stopping the drug.

Avoid grapefruit as it can increase your chance of experiencing side effects. An erection involves several different factors, so it is important to understand the process. This can help to give you an understanding of why Viagra doesn’t always work.

If this occurs, we advise that you seek emergency treatment immediately. Medicines that you take by mouth are called oral medicines. They're often the first line of treatment for trouble getting or keeping an erection, called erectile dysfunction (ED). Oral medicines for ED usually work well and cause few side effects. If you are going to be using its effects everyday, there is no reason why you cannot use it daily.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed. The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time. Nitrates are found in medications that are used to treat angina (chest pain). If you are not sure if you are taking nitrates, ask your doctor or pharmacist.

Based on our interviews and focus groups with men who have used telehealth platforms like Blink Health for ED medications, we found that many had a similar story. Many participants described how ED symptoms started subtly and they began to notice an intermittent decline in erections but did not seek medical care right away. If you’re experiencing sexual dysfunction, taking Viagra won’t help to resolve your symptoms and could lead to harmful side effects. The medication isn’t licensed for use by women and could cause potentially serious health issues.

Tell your doctor if sildenafil is not working well or if you are experiencing side effects. These factors may affect how you should use this medication. Viagra is used as needed, meaning you only take a dose prior to sexual activity. Cialis can be prescribed for use as needed, but can also be prescribed for use once per day, every day (without timing the dose around sexual activity).

Other drugs that operate by the same mechanism include tadalafil (Cialis) and vardenafil (Levitra). Consider a starting dose of 25 mg in patients treated with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, or saquinavir) or erythromycin. Clinical data have shown that co-administration with saquinavir or erythromycin increased plasma levels of sildenafil by about 3 fold [see Drug Interactions (7.4) and Clinical Pharmacology (12.3)]. Population pharmacokinetic analysis of clinical trial data indicated a reduction in sildenafil clearance when co-administered with CYP3A4 inhibitors (such as ketoconazole, erythromycin, cimetidine). Although no increased incidence of adverse events was observed in these patients, when sildenafil is administered concomitantly with CYP3A4 inhibitors, a starting dose of 25 mg should be considered. Most, but not all, of these patients had pre-existing cardiovascular risk factors.

But your doctor might prescribe a lower starting dosage of 25 mg depending on several factors. A review of population subgroups demonstrated efficacy regardless of baseline severity, etiology, race and age. Sildenafil at steady state, at a dose not approved for the treatment of erectile dysfunction (80 mg t.i.d.) resulted in a 50% increase in AUC and a 42% increase in Cmax of bosentan (125 mg b.i.d.). The most common adverse reactions reported in clinical trials (≥ 2%) are headache, flushing, dyspepsia, abnormal vision, nasal congestion, back pain, myalgia, nausea, dizziness, and rash. VIAGRA has systemic vasodilatory properties and may further lower blood pressure in patients taking anti-hypertensive medications.

Revatio and these forms of sildenafil are used to treat pulmonary arterial hypertension (PAH). With PAH, you have high blood pressure in the artery between your heart and lungs. Viagra (sildenafil) is a prescription drug that’s used to treat erectile dysfunction (ED). It’s usually taken as needed about 1 hour before sexual activity. The effectiveness of VIAGRA was evaluated in most studies using several assessment instruments.

These side effects include headaches, flushing, indigestion, nasal congestion, and changes in your vision. So if these side effects are a problem for you, talk with your doctor about taking a lower dosage of Viagra. If you have chest pain after taking Viagra, you should stop sexual activity right away. But call 911 if your symptoms feel life threatening or if you think you’re having a medical emergency. ED can occur if you have certain problems that affect your body’s ability to have an erection. The condition can result from problems with messages being sent from your brain.

If you’ve been waiting longer than this, please email and we’ll look into it. No, sildenafil is not available as an over-the-counter medication in Canada. In order to access sildenafil, you must first speak with a licensed healthcare practitioner, like those at Felix.

Single doses of antacid (magnesium hydroxide/aluminum hydroxide) did not affect the bioavailability of VIAGRA. Although the interaction between other protease inhibitors and sildenafil has not been studied, their concomitant use is expected to increase sildenafil levels. Cimetidine (800 mg), a nonspecific CYP inhibitor, caused a 56% increase in plasma sildenafil concentrations when co-administered with VIAGRA (50 mg) to healthy volunteers. In addition, N-desmethyl metabolite AUC and Cmax values significantly increased by 200% and 79%, respectively in subjects with severe renal impairment compared to subjects with normal renal function. The mean profiles of the change from baseline in standing systolic blood pressure in subjects treated with doxazosin in combination with 100 mg VIAGRA or matching placebo are shown in Figure 4.

A stronger CYP3A4 inhibitor such as ketoconazole or itraconazole could be expected to have greater effect than that seen with saquinavir. The results from this pilot study are shown in Table 3